After I applied the product he started freaking out and tried to rub it off for a good hour. After that he just laid and stayed in place but I could tell something was wrong. I left him alone because I figured he would get over it as he usually does when I use Frontline on him. The next day my brother started noticing his ears twitching one at a time consistently. After my brother told me what he noticed I washed him immediately and then I washed him immediately again after that and made sure I washed that stuff off. I know by now its in his blood stream but I don't give him Benadryl like some people or should I wait it out? I don't know what to do. I feel so guilty for not reading aout this stuff first